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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2520
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd2
Name: dopamine receptor D2
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd2affects expressionEXP 6480464CTDCocaine affects the expression of DRD2; Cocaine affects the expression of DRD2 mRNA; Cocaine affects the expression of DRD2 proteinPMID:12892653 PMID:17544385 PMID:18990547 PMID:20435100
Drd2affects response to substanceEXP 6480464CTDDRD2 protein affects the susceptibility to CocainePMID:2213551
Drd2decreases expressionEXP 6480464CTDCocaine results in decreased expression of DRD2 mRNA; Cocaine results in decreased expression of DRD2 proteinPMID:18305460
Drd2increases activityEXP 6480464CTDCocaine results in increased activity of DRD2 proteinPMID:19046384
Drd2increases expressionEXP 6480464CTDCocaine results in increased expression of DRD2 mRNA; Cocaine results in increased expression of DRD2 proteinPMID:11602327 PMID:15042275 PMID:15049517
Drd2multiple interactionsEXP 6480464CTDCocaine affects the reaction [Spiperone binds to DRD2 protein]; Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]; Methadone affects the reaction [Cocaine affects the expression of DRD2 mRNA]; Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]PMID:17161392 PMID:18990547 PMID:20729865
Drd2decreases expressionISODRD2 (Homo sapiens)6480464CTDCocaine results in decreased expression of DRD2 mRNA; Cocaine results in decreased expression of DRD2 proteinPMID:11126397 PMID:18000554 PMID:19723785 PMID:9892293
Drd2decreases response to substanceISODrd2 (Mus musculus)6480464CTDDRD2 protein results in decreased susceptibility to CocainePMID:11923462
Drd2increases expressionISODrd2 (Mus musculus)6480464CTDCocaine deficiency results in increased expression of DRD2 mRNA; Cocaine results in increased expression of DRD2 proteinPMID:27126842 PMID:35597300
Drd2increases response to substanceISODrd2 (Mus musculus)6480464CTDDRD2 results in increased susceptibility to CocainePMID:11790512
Drd2increases response to substanceISODRD2 (Homo sapiens)6480464CTDDRD2 polymorphism results in increased susceptibility to CocainePMID:17671965
Drd2multiple interactionsISODrd2 (Mus musculus)6480464CTDPDYN protein affects the reaction [Cocaine affects the expression of DRD2 protein]PMID:17532787
Drd2multiple interactionsISODRD2 (Homo sapiens)6480464CTDCocaine affects the reaction [Raclopride binds to DRD2]PMID:15010698
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