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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases activityEXP 6480464CTDCocaine results in increased activity of BAX proteinPMID:17635674
Baxincreases expressionEXP 6480464CTDCocaine results in increased expression of BAX proteinPMID:11392460 PMID:15685203 PMID:17084983 PMID:17635674 PMID:18974856
Baxaffects expressionISOBax (Mus musculus)6480464CTDCocaine affects the expression of BAX mRNAPMID:15681117
Baxincreases expressionISOBax (Mus musculus)6480464CTDCocaine results in increased expression of BAX proteinPMID:29673861 PMID:30393195
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDCocaine results in increased expression of BAX mRNAPMID:20948987
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDADCYAP1 protein modified form affects the reaction [Cocaine results in increased expression of BAX protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [Cocaine results in increased expression of BAX protein]; IL6 protein affects the reaction [Cocaine results in increased expression of BAX protein]; TNF protein affects the reaction [Cocaine results in increased expression of BAX protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of BAX protein]]PMID:29673861
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