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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2038
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adcyap1r1
Name: ADCYAP receptor type I
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:100856480464CTDCocaine results in increased expression of ADCYAP1R1 mRNA

PMID:29673861
multiple interactionsISORGD:100856480464CTDalpha-cyano-(3, 4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]], alpha-cyano-(3, 4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA], IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA], TNF protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]

PMID:29673861
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.