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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1557983
Species: Mus musculus
RGD Object: Gene
Symbol: Grm2
Name: glutamate receptor, metabotropic 2
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grm2affects expressionISOGrm2 (Rattus norvegicus)6480464CTDCocaine affects the expression of GRM2 proteinPMID:19105975
Grm2decreases activityISOGrm2 (Rattus norvegicus)6480464CTDCocaine results in decreased activity of GRM2 proteinPMID:18673447
Grm2increases activityISOGrm2 (Rattus norvegicus)6480464CTDCocaine results in increased activity of GRM2 proteinPMID:20416862
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