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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 13915338
Species: Sus scrofa
RGD Object: Gene
Symbol: EDN1
Name: endothelin 1
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EDN1increases expressionEXP 6480464CTDCocaine results in increased expression of EDN1 protein

PMID:9714087
EDN1multiple interactionsEXP 6480464CTD1 3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein] Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]

PMID:9714087
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