GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | IL6 | decreases expression | EXP | | 6480464 | CTD | Cocaine results in decreased expression of IL6 protein | PMID:17068203 | IL6 | affects response to substance | ISO | Il6 (Mus musculus) | 6480464 | CTD | IL6 protein affects the susceptibility to Cocaine | PMID:29673861 | IL6 | decreases expression | ISO | Il6 (Rattus norvegicus) | 6480464 | CTD | Cocaine results in decreased expression of IL6 protein | PMID:10864098 | IL6 | increases expression | ISO | Il6 (Mus musculus) | 6480464 | CTD | Cocaine results in increased expression of IL6 mRNA; Cocaine results in increased expression of IL6 protein | PMID:29673861 | IL6 | multiple interactions | ISO | Il6 (Mus musculus) | 6480464 | CTD | [IL6 protein affects the susceptibility to Cocaine] which affects the expression of TNF mRNA; [IL6 protein affects the susceptibility to Cocaine] which affects the expression of TNF protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased phosphorylation of JAK2 protein]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased phosphorylation of STAT3 protein]]; IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]; IL6 protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]; IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]; IL6 protein affects the reaction [Cocaine results in increased expression of BAX protein]; IL6 protein affects the reaction [Cocaine results in increased phosphorylation of JAK2 protein]; IL6 protein affects the reaction [Cocaine results in increased phosphorylation of STAT3 protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of BAX protein]]; TNF protein affects the reaction [IL6 protein affects the susceptibility to Cocaine] | PMID:29673861 | | ||||||||||||||||||||||
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