GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Fosb | increases expression | EXP | | 401901287 | RGD | cocaine increases expression of Fosb protein in dorsal striatum and nucelus accumbens | | Fosb | increases expression | ISO | Fosb (Rattus norvegicus) | 401851063 | RGD | cocaine increases expression of Fosb protein in Nucleus Accumbens and Caudate Putamen | | Fosb | increases expression | ISO | Fosb (Rattus norvegicus) | 401851078 | RGD | cocaine increases expression of Fosb protein in Brain | | Fosb | increases expression | ISO | Fosb (Rattus norvegicus) | 401851084 | RGD | Cocaine increases expression of Fosb protein in brain | | Fosb | increases expression | ISO | Fosb (Rattus norvegicus) | 401900126 | RGD | Cocaine increases expression of Fosb mRNA and protein in Nucleus Accumbens and Caudate Putamen | | Fosb | increases expression | ISO | Fosb (Rattus norvegicus) | 401900166 | RGD | Cocaine increases expression of Fosb protein in Nucleus Accumbens and Caudate putamen | | Fosb | increases expression | ISO | Fosb (Rattus norvegicus) | 401900302 | RGD | Cocaine increases expression of Fosb protein in caudate���putamen | | Fosb | affects expression | EXP | | 6480464 | CTD | Cocaine affects the expression of FOSB mRNA | PMID:18355967 | Fosb | increases expression | EXP | | 6480464 | CTD | Cocaine results in increased expression of FOSB mRNA; Cocaine results in increased expression of FOSB protein; Cocaine results in increased expression of FOSB protein alternative form | PMID:10103106 PMID:12417638 PMID:16710312 PMID:20056891 | Fosb | multiple interactions | EXP | | 6480464 | CTD | [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein; [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSB protein; [JUND protein results in decreased activity of FOSB protein] which results in decreased susceptibility to Cocaine; Cocaine inhibits the reaction [Cocaine promotes the reaction [EHMT2 protein binds to FOSB protein]]; Cocaine promotes the reaction [EHMT2 protein binds to FOSB protein]; EHMT2 protein inhibits the reaction [Cocaine results in increased expression of FOSB mRNA]; N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form]; PPP1R1B gene mutant form inhibits the reaction [Cocaine results in increased expression of FOSB protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form] | PMID:10103106 PMID:15056714 PMID:16263220 PMID:16710312 PMID:20056891 | Fosb | affects expression | ISO | Fosb (Rattus norvegicus) | 6480464 | CTD | Cocaine affects the expression of FOSB mRNA; Cocaine affects the expression of FOSB protein | PMID:20633205 | Fosb | increases expression | ISO | Fosb (Rattus norvegicus) | 6480464 | CTD | Cocaine results in increased expression of FOSB mRNA; Cocaine results in increased expression of FOSB protein; Cocaine results in increased expression of FOSB protein alternative form | PMID:11391778 PMID:11739600 PMID:15926929 PMID:16674926 PMID:17898221 PMID:18293355 PMID:18822274 PMID:27899881 | Fosb | increases expression | ISO | FOSB (Homo sapiens) | 6480464 | CTD | Cocaine results in increased expression of FOSB protein | PMID:15814102 | Fosb | multiple interactions | ISO | Fosb (Rattus norvegicus) | 6480464 | CTD | DRD1 protein affects the reaction [Cocaine results in increased expression of FOSB protein alternative form]; DRD1 protein affects the reaction [Cocaine results in increased expression of FOSB protein]; SCH 23390 inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form]; SCH 23390 inhibits the reaction [Cocaine results in increased expression of FOSB protein] | PMID:16674926 PMID:18822274 | | ||||||||||||||||||||||
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