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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1302972
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ehmt2
Name: euchromatic histone lysine methyltransferase 2
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ehmt2decreases expressionISOEhmt2 (Mus musculus)6480464CTDCocaine results in decreased expression of EHMT2 mRNA; Cocaine results in decreased expression of EHMT2 proteinPMID:20056891
Ehmt2decreases response to substanceISOEhmt2 (Mus musculus)6480464CTDEHMT2 results in decreased susceptibility to CocainePMID:20056891
Ehmt2multiple interactionsISOEhmt2 (Mus musculus)6480464CTDCocaine inhibits the reaction [Cocaine promotes the reaction [EHMT2 protein binds to FOSB protein]]; Cocaine promotes the reaction [EHMT2 protein binds to FOSB protein]; EHMT2 inhibits the reaction [Cocaine results in increased expression of ATM mRNA]; EHMT2 inhibits the reaction [Cocaine results in increased expression of ELMO1 mRNA]; EHMT2 inhibits the reaction [Cocaine results in increased expression of TGFBR1 mRNA]; EHMT2 inhibits the reaction [Cocaine results in increased expression of TNFRSF25 mRNA]; EHMT2 inhibits the reaction [Cocaine results in increased expression of USP9X mRNA]; EHMT2 inhibits the reaction [Cocaine results in increased expression of WNK3 mRNA]; EHMT2 protein inhibits the reaction [Cocaine results in increased expression of FOSB mRNA]PMID:20056891
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