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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349272
Species: Homo sapiens
RGD Object: Gene
Symbol: PON1
Name: paraoxonase 1
Acc ID: CHEBI:27928
Term: parathion
Definition: An organothiophosphate insecticide that has formula C10H14NO5PS.
Chemical ID: MESH:D010278
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PON1increases hydrolysisEXP 6480464CTDPON1 protein results in increased hydrolysis of ParathionPMID:16331452
PON1increases metabolic processingEXP 6480464CTDPON1 gene mutant form results in increased metabolism of ParathionPMID:12625227
PON1increases expressionISOPon1 (Mus musculus)6480464CTDParathion results in increased expression of PON1 mRNAPMID:34813904
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