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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621104
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a25
Name: solute carrier family 22, member 25
Acc ID: CHEBI:27902
Term: tetracycline
Definition: A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.
Chemical ID: MESH:D013752
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases exportISORGD:13439506480464CTDSLC22A9 protein results in increased export of Tetracycline

PMID:11855680
increases uptakeISORGD:13439506480464CTDSLC22A9 protein results in increased uptake of Tetracycline

PMID:11855680
multiple interactionsISORGD:13439506480464CTDTetracycline inhibits the reaction [SLC22A9 protein results in increased uptake of Anions]

PMID:11855680
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.