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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737039
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN2A
Name: cyclin dependent kinase inhibitor 2A
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN2Adecreases expressionEXP 6480464CTDCisplatin results in decreased expression of CDKN2A proteinPMID:16797627
CDKN2Aincreases expressionEXP 6480464CTDCisplatin results in increased expression of CDKN2A mRNA; Cisplatin results in increased expression of CDKN2A proteinPMID:16797627 PMID:20540955
CDKN2Amultiple interactionsEXP 6480464CTD[Cisplatin co-treated with Quercetin] results in increased expression of CDKN2A mRNA; [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of CDKN2A mRNAPMID:27514524 PMID:30871063
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