Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	737013
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	TLR4
Name:	toll like receptor 4

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
TLR4	increases expression	EXP		6480464	CTD	Cisplatin results in increased expression of TLR4 mRNA	PMID:27392435
TLR4	increases expression	ISO	Tlr4 (Rattus norvegicus)	6480464	CTD	Cisplatin results in increased expression of TLR4 mRNA; Cisplatin results in increased expression of TLR4 protein	PMID:28371137 PMID:32259551 PMID:32418911
TLR4	increases expression	ISO	Tlr4 (Mus musculus)	6480464	CTD	Cisplatin results in increased expression of TLR4 mRNA; Cisplatin results in increased expression of TLR4 protein	PMID:21148032 PMID:26546572
TLR4	multiple interactions	ISO	Tlr4 (Rattus norvegicus)	6480464	CTD	crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]; Grape Seed Proanthocyanidins inhibits the reaction [Cisplatin results in increased expression of TLR4 mRNA]; Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]	PMID:28371137 PMID:32259551 PMID:32418911
TLR4	multiple interactions	ISO	Tlr4 (Mus musculus)	6480464	CTD	[Cisplatin co-treated with Lipopolysaccharides] results in increased expression of TLR4 protein; [Cisplatin promotes the reaction [Lipopolysaccharides binds to TLR4 protein]] which results in increased expression of IL1B protein; [Cisplatin promotes the reaction [Lipopolysaccharides binds to TLR4 protein]] which results in increased expression of IL6 protein; [Cisplatin promotes the reaction [Lipopolysaccharides binds to TLR4 protein]] which results in increased expression of TNF protein; [Cisplatin promotes the reaction [Lipopolysaccharides binds to TLR4 protein]] which results in increased phosphorylation of NFKBIA protein; TLR4 protein promotes the reaction [[Cisplatin co-treated with Lipopolysaccharides] results in increased expression of TNF protein]	PMID:21148032

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