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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736747
Species: Homo sapiens
RGD Object: Gene
Symbol: ALDH1A1
Name: aldehyde dehydrogenase 1 family member A1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ALDH1A1decreases expressionEXP 6480464CTDCisplatin results in decreased expression of ALDH1A1 mRNAPMID:11099651
ALDH1A1increases expressionEXP 6480464CTDCisplatin results in increased expression of ALDH1A1 mRNA; Cisplatin results in increased expression of ALDH1A1 proteinPMID:33969609
ALDH1A1multiple interactionsEXP 6480464CTD[Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of ALDH1A1 mRNA; FTL protein affects the reaction [Cisplatin results in increased expression of ALDH1A1 protein]PMID:30871063 PMID:33969609
ALDH1A1increases expressionISOAldh1a1 (Mus musculus)6480464CTDCisplatin results in increased expression of ALDH1A1 mRNAPMID:21151649
ALDH1A1increases expressionISOAldh1a1 (Rattus norvegicus)6480464CTDCisplatin results in increased expression of ALDH1A1 mRNAPMID:18289764 PMID:22023808
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