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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736600
Species: Homo sapiens
RGD Object: Gene
Symbol: CD59
Name: CD59 molecule (CD59 blood group)
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CD59decreases expressionEXP 6480464CTDCisplatin results in decreased expression of CD59 proteinPMID:24798381
CD59multiple interactionsEXP 6480464CTD[Cisplatin co-treated with Etoposide] results in decreased expression of CD59 protein; [Cisplatin co-treated with jinfukang] results in decreased expression of CD59 mRNAPMID:21826740 PMID:27392435
CD59decreases lipidationISOCd59b (Rattus norvegicus)6480464CTDCisplatin results in decreased lipidation of CD59 proteinPMID:27931811
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