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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736265
Species: Homo sapiens
RGD Object: Gene
Symbol: TRIM28
Name: tripartite motif containing 28
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TRIM28multiple interactionsEXP 6480464CTD[Piroxicam co-treated with Cisplatin] results in decreased expression of TRIM28 mRNAPMID:21858171
TRIM28increases phosphorylationISOTrim28 (Mus musculus)6480464CTDCisplatin results in increased phosphorylation of TRIM28 proteinPMID:22006019
TRIM28multiple interactionsISOTrim28 (Mus musculus)6480464CTD[2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein] inhibits the reaction [Cisplatin results in increased phosphorylation of TRIM28 protein]PMID:22003191
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