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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736015
Species: Homo sapiens
RGD Object: Gene
Symbol: ACACA
Name: acetyl-CoA carboxylase alpha
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACACAaffects expressionEXP 6480464CTDCisplatin affects the expression of ACACA mRNAPMID:23300844
ACACAdecreases expressionEXP 6480464CTDCisplatin results in decreased expression of ACACA mRNAPMID:19561079 PMID:25450742 PMID:27594783
ACACAdecreases phosphorylationISOAcaca (Mus musculus)6480464CTDCisplatin results in decreased phosphorylation of ACACA proteinPMID:22006019
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