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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735938
Species: Homo sapiens
RGD Object: Gene
Symbol: ANXA4
Name: annexin A4
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ANXA4affects localizationEXP 6480464CTDCisplatin affects the localization of ANXA4 proteinPMID:24150977
ANXA4increases expressionEXP 6480464CTDCisplatin results in increased expression of ANXA4 mRNAPMID:27392435
ANXA4multiple interactionsEXP 6480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of ANXA4 mRNA; ATP7A protein promotes the reaction [ANXA4 protein results in decreased susceptibility to Cisplatin]PMID:24150977 PMID:27392435
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