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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735751
Species: Homo sapiens
RGD Object: Gene
Symbol: MAOA
Name: monoamine oxidase A
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAOAaffects expressionEXP 6480464CTDCisplatin affects the expression of MAOA mRNAPMID:23300844
MAOAincreases expressionEXP 6480464CTDCisplatin results in increased expression of MAOA mRNA; Cisplatin results in increased expression of MAOA proteinPMID:34560070
MAOAmultiple interactionsEXP 6480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of MAOA mRNA; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of MAOA protein]PMID:27392435 PMID:34560070
MAOAincreases expressionISOMaoa (Mus musculus)6480464CTDCisplatin results in increased expression of MAOA mRNA; Cisplatin results in increased expression of MAOA proteinPMID:15464296 PMID:15471895 PMID:21151649 PMID:34560070
MAOAmultiple interactionsISOMaoa (Mus musculus)6480464CTD[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; Carbidopa inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of MAOA protein]PMID:34560070
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