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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735389
Species: Homo sapiens
RGD Object: Gene
Symbol: BBC3
Name: BCL2 binding component 3
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BBC3increases expressionEXP 6480464CTDCisplatin results in increased expression of BBC3 mRNA; Cisplatin results in increased expression of BBC3 proteinPMID:16481741 PMID:21109480 PMID:21285353 PMID:21516125 PMID:21527555 PMID:21532991 PMID:25596134 PMID:27594783 PMID:29690507 PMID:34126102 PMID:35259468
BBC3increases response to substanceEXP 6480464CTDBBC3 protein results in increased susceptibility to CisplatinPMID:16481741 PMID:21532991
BBC3multiple interactionsEXP 6480464CTD2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one promotes the reaction [Cisplatin results in increased expression of BBC3 mRNA]; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in decreased expression of BBC3 mRNA; [[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein] which results in increased expression of BBC3 protein; Cisplatin inhibits the reaction [[HDAC1 protein co-treated with TP63 protein modified form] binds to BBC3 promoter]; Cisplatin promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]; MSH2 protein promotes the reaction [Cisplatin results in increased expression of BBC3 protein]; nutlin 3 promotes the reaction [Cisplatin results in increased expression of BBC3 mRNA]; TP53 protein affects the reaction [Cisplatin results in increased expression of BBC3 mRNA]; TP73 protein modified form promotes the reaction [Cisplatin results in increased expression of BBC3 protein]; Tretinoin inhibits the reaction [Cisplatin results in increased expression of BBC3 mRNA]; xanthohumol promotes the reaction [Cisplatin results in increased expression of BBC3 protein]PMID:20686837 PMID:21109480 PMID:21285353 PMID:21516125 PMID:21527555 PMID:21532991 PMID:29690507 PMID:32800223 PMID:35259468
BBC3affects response to substanceISOBbc3 (Mus musculus)6480464CTDBBC3 protein affects the susceptibility to CisplatinPMID:20477944
BBC3increases expressionISOBbc3 (Mus musculus)6480464CTDCisplatin results in increased expression of BBC3 proteinPMID:21285353 PMID:21593185 PMID:21633170 PMID:24560772 PMID:26193055
BBC3increases expressionISOBbc3 (Rattus norvegicus)6480464CTDCisplatin results in increased expression of BBC3 proteinPMID:20650967 PMID:35842499
BBC3multiple interactionsISOBbc3 (Mus musculus)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in increased expression of BBC3 protein]]; erdosteine inhibits the reaction [Cisplatin results in increased expression of BBC3 protein]; MSH2 protein promotes the reaction [Cisplatin results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in increased expression of BBC3 protein]]]; resveratrol inhibits the reaction [Cisplatin results in increased expression of BBC3 protein]; SB 216763 inhibits the reaction [Cisplatin results in increased expression of BBC3 protein]PMID:21285353 PMID:21593185 PMID:24560772 PMID:26193055
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