GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | BBC3 | increases expression | EXP | | 6480464 | CTD | Cisplatin results in increased expression of BBC3 mRNA; Cisplatin results in increased expression of BBC3 protein | PMID:16481741 PMID:21109480 PMID:21285353 PMID:21516125 PMID:21527555 PMID:21532991 PMID:25596134 PMID:27594783 PMID:29690507 PMID:34126102 PMID:35259468 | BBC3 | increases response to substance | EXP | | 6480464 | CTD | BBC3 protein results in increased susceptibility to Cisplatin | PMID:16481741 PMID:21532991 | BBC3 | multiple interactions | EXP | | 6480464 | CTD | 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one promotes the reaction [Cisplatin results in increased expression of BBC3 mRNA]; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in decreased expression of BBC3 mRNA; [[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein] which results in increased expression of BBC3 protein; Cisplatin inhibits the reaction [[HDAC1 protein co-treated with TP63 protein modified form] binds to BBC3 promoter]; Cisplatin promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]; MSH2 protein promotes the reaction [Cisplatin results in increased expression of BBC3 protein]; nutlin 3 promotes the reaction [Cisplatin results in increased expression of BBC3 mRNA]; TP53 protein affects the reaction [Cisplatin results in increased expression of BBC3 mRNA]; TP73 protein modified form promotes the reaction [Cisplatin results in increased expression of BBC3 protein]; Tretinoin inhibits the reaction [Cisplatin results in increased expression of BBC3 mRNA]; xanthohumol promotes the reaction [Cisplatin results in increased expression of BBC3 protein] | PMID:20686837 PMID:21109480 PMID:21285353 PMID:21516125 PMID:21527555 PMID:21532991 PMID:29690507 PMID:32800223 PMID:35259468 | BBC3 | affects response to substance | ISO | Bbc3 (Mus musculus) | 6480464 | CTD | BBC3 protein affects the susceptibility to Cisplatin | PMID:20477944 | BBC3 | increases expression | ISO | Bbc3 (Mus musculus) | 6480464 | CTD | Cisplatin results in increased expression of BBC3 protein | PMID:21285353 PMID:21593185 PMID:21633170 PMID:24560772 PMID:26193055 | BBC3 | increases expression | ISO | Bbc3 (Rattus norvegicus) | 6480464 | CTD | Cisplatin results in increased expression of BBC3 protein | PMID:20650967 PMID:35842499 | BBC3 | multiple interactions | ISO | Bbc3 (Mus musculus) | 6480464 | CTD | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in increased expression of BBC3 protein]]; erdosteine inhibits the reaction [Cisplatin results in increased expression of BBC3 protein]; MSH2 protein promotes the reaction [Cisplatin results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in increased expression of BBC3 protein]]]; resveratrol inhibits the reaction [Cisplatin results in increased expression of BBC3 protein]; SB 216763 inhibits the reaction [Cisplatin results in increased expression of BBC3 protein] | PMID:21285353 PMID:21593185 PMID:24560772 PMID:26193055 | |
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