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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735194
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Snap47
Name: synaptosome associated protein 47
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Snap47decreases response to substanceISOSNAP47 (Homo sapiens)6480464CTDSNAP47 mRNA alternative form results in decreased susceptibility to CisplatinPMID:34664776
Snap47multiple interactionsISOSNAP47 (Homo sapiens)6480464CTD[[SNAP47 mRNA alternative form results in decreased expression of MIR625 mRNA] which results in increased expression of WEE1 protein] which results in decreased susceptibility to Cisplatin; [Cisplatin co-treated with jinfukang] results in increased expression of SNAP47 mRNAPMID:27392435 PMID:34664776
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