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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733814
Species: Mus musculus
RGD Object: Gene
Symbol: Bnip3
Name: BCL2/adenovirus E1B interacting protein 3
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bnip3increases expressionEXP 6480464CTDCisplatin results in increased expression of BNIP3 mRNAPMID:21074548
Bnip3increases phosphorylationEXP 6480464CTDCisplatin results in increased phosphorylation of BNIP3 proteinPMID:22006019
Bnip3affects expressionISOBNIP3 (Homo sapiens)6480464CTDCisplatin affects the expression of BNIP3 mRNAPMID:23300844
Bnip3decreases expressionISOBNIP3 (Homo sapiens)6480464CTDCisplatin results in decreased expression of BNIP3 mRNAPMID:29690507
Bnip3increases expressionISOBnip3 (Rattus norvegicus)6480464CTDCisplatin results in increased expression of BNIP3 mRNA; Cisplatin results in increased expression of BNIP3 proteinPMID:21575413 PMID:25598344
Bnip3multiple interactionsISOBNIP3 (Homo sapiens)6480464CTD[Cisplatin co-treated with Berberine] results in increased expression of BNIP3 protein; [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of BNIP3 mRNA; [eprenetapopt co-treated with Cisplatin] results in decreased expression of BNIP3 mRNA; Oxygen deficiency inhibits the reaction [[eprenetapopt co-treated with Cisplatin] results in decreased expression of BNIP3 mRNA]; Oxygen deficiency inhibits the reaction [Cisplatin results in decreased expression of BNIP3 mRNA]PMID:29690507 PMID:30871063 PMID:36070022
Bnip3multiple interactionsISOBnip3 (Rattus norvegicus)6480464CTDsaponin Rb1, Panax notoginsenoside promotes the reaction [Cisplatin results in increased expression of BNIP3 protein]PMID:25598344
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