GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | XRCC1 | decreases response to substance | EXP | | 6480464 | CTD | XRCC1 mRNA results in decreased susceptibility to Cisplatin; XRCC1 protein results in decreased susceptibility to Cisplatin | PMID:15882455 PMID:19853026 | XRCC1 | increases expression | EXP | | 6480464 | CTD | Cisplatin results in increased expression of XRCC1 mRNA | PMID:27594783 | XRCC1 | multiple interactions | EXP | | 6480464 | CTD | [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of XRCC1 mRNA; XRCC1 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with Cisplatin] | PMID:22452940 PMID:30871063 | |
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