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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732557
Species: Homo sapiens
RGD Object: Gene
Symbol: VDAC1
Name: voltage dependent anion channel 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
VDAC1decreases expressionEXP 6480464CTDCisplatin results in decreased expression of VDAC1 mRNAPMID:27594783
VDAC1multiple interactionsEXP 6480464CTD[arsenic trioxide results in increased expression of VDAC1 protein] which results in increased susceptibility to CisplatinPMID:22285227
VDAC1multiple interactionsISOVdac1 (Rattus norvegicus)6480464CTDCisplatin promotes the reaction [VDAC1 protein binds to VDAC1 protein]PMID:20937774
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