Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	732271
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	MAPK8
Name:	mitogen-activated protein kinase 8

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
MAPK8	increases phosphorylation	EXP		6480464	CTD	Cisplatin results in increased phosphorylation of MAPK8 protein	PMID:30550853 PMID:32238696 PMID:36070022
MAPK8	multiple interactions	EXP		6480464	CTD	[Berberine co-treated with Cisplatin] results in increased phosphorylation of MAPK8 protein; [Cisplatin co-treated with 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid] results in increased phosphorylation of MAPK8 protein; [Cisplatin co-treated with hesperetin] results in decreased phosphorylation of MAPK8 protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]; Cisplatin results in increased phosphorylation of and results in increased activity of MAPK8 protein; Nicotine inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; TRAF2 protein affects the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]	PMID:11592233 PMID:21214929 PMID:30550853 PMID:31153982 PMID:32238696 PMID:36070022
MAPK8	increases expression	ISO	Mapk8 (Rattus norvegicus)	6480464	CTD	Cisplatin results in increased expression of MAPK8 protein modified form	PMID:26739623
MAPK8	increases expression	ISO	Mapk8 (Mus musculus)	6480464	CTD	Cisplatin results in increased expression of MAPK8 mRNA	PMID:20883750
MAPK8	increases phosphorylation	ISO	Mapk8 (Rattus norvegicus)	6480464	CTD	Cisplatin results in increased phosphorylation of MAPK8 protein	PMID:15147517
MAPK8	increases phosphorylation	ISO	Mapk8 (Mus musculus)	6480464	CTD	Cisplatin results in increased phosphorylation of MAPK8 protein	PMID:31153982 PMID:32991863 PMID:35304134 PMID:36965608
MAPK8	multiple interactions	ISO	Mapk8 (Rattus norvegicus)	6480464	CTD	Lovastatin inhibits the reaction [Cisplatin results in increased expression of MAPK8 protein modified form]; N-Acetylcysteinamide inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]	PMID:15147517 PMID:26739623
MAPK8	multiple interactions	ISO	Mapk8 (Mus musculus)	6480464	CTD	anemoside B4 inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]; hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]; PARK7 protein affects the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]; Rutin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]	PMID:31153982 PMID:32991863 PMID:35304134 PMID:36965608

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