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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732257
Species: Homo sapiens
RGD Object: Gene
Symbol: GSTP1
Name: glutathione S-transferase pi 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSTP1affects response to substanceEXP 6480464CTDGSTP1 gene affects the susceptibility to Cisplatin; GSTP1 gene polymorphism affects the susceptibility to Cisplatin; GSTP1 mRNA affects the susceptibility to CisplatinPMID:12360105 PMID:16785472 PMID:8055443
GSTP1decreases response to substanceEXP 6480464CTDGSTP1 protein results in decreased susceptibility to Cisplatin; GSTP1 results in decreased susceptibility to CisplatinPMID:14678959 PMID:15279901 PMID:19396019
GSTP1increases expressionEXP 6480464CTDCisplatin results in increased expression of GSTP1 mRNAPMID:27392435
GSTP1increases response to substanceEXP 6480464CTDGSTP1 mRNA results in increased susceptibility to CisplatinPMID:15239142
GSTP1multiple interactionsEXP 6480464CTD[[PRKCA protein results in increased phosphorylation of GSTP1 protein] which results in increased metabolism of Cisplatin] which results in decreased susceptibility to Cisplatin; [Cisplatin co-treated with Fluorouracil] results in decreased expression of GSTP1 mRNA; [PRKCA protein results in increased phosphorylation of GSTP1 protein] which results in increased metabolism of Cisplatin; GSTP1 gene polymorphism results in decreased susceptibility to [Fluorouracil co-treated with Cisplatin]PMID:15737843 PMID:16622263 PMID:20654585
GSTP1decreases response to substanceISOGstp1 (Rattus norvegicus)6480464CTDGSTP1 protein results in decreased susceptibility to CisplatinPMID:11455017
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