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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732178
Species: Homo sapiens
RGD Object: Gene
Symbol: AKR1B1
Name: aldo-keto reductase family 1 member B
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKR1B1decreases expressionEXP 6480464CTDCisplatin results in decreased expression of AKR1B1 proteinPMID:16803524
AKR1B1increases expressionISOAkr1b1 (Rattus norvegicus)6480464CTDCisplatin results in increased expression of AKR1B1 mRNAPMID:18172885
AKR1B1increases phosphorylationISOAkr1b1 (Mus musculus)6480464CTDCisplatin results in increased phosphorylation of AKR1B1 proteinPMID:22006019
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