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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731820
Species: Homo sapiens
RGD Object: Gene
Symbol: CDH2
Name: cadherin 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDH2decreases expression EXP 127284886RGDcisplatin decreases expression of CDH2 protein in stomach 
CDH2decreases expressionEXP 6480464CTDCisplatin results in decreased expression of CDH2 mRNAPMID:27392435
CDH2increases expressionEXP 6480464CTDCisplatin results in increased expression of CDH2 proteinPMID:21618587
CDH2multiple interactionsEXP 6480464CTD[Cisplatin co-treated with jinfukang] results in decreased expression of CDH2 mRNA; [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of CDH2 mRNAPMID:27392435 PMID:30871063
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