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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731755
Species: Homo sapiens
RGD Object: Gene
Symbol: DHCR7
Name: 7-dehydrocholesterol reductase
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DHCR7affects expressionEXP 6480464CTDCisplatin affects the expression of DHCR7 mRNAPMID:27594783
DHCR7decreases expressionEXP 6480464CTDCisplatin results in decreased expression of DHCR7 mRNAPMID:24280081
DHCR7multiple interactionsEXP 6480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of DHCR7 mRNA; [Cisplatin co-treated with Paclitaxel] results in increased expression of DHCR7 mRNAPMID:20705681 PMID:27392435
DHCR7decreases expressionISODhcr7 (Mus musculus)6480464CTDCisplatin results in decreased expression of DHCR7 mRNAPMID:24280081
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