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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731748
Species: Homo sapiens
RGD Object: Gene
Symbol: JAK2
Name: Janus kinase 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
JAK2decreases phosphorylationEXP 127284886RGDcisplatin decreases phosphorylation of JAK2 protein in stomach 
JAK2increases expression ISOJak2 (Mus musculus)149735351RGDcisplatin increases expression of Jak2 mRNA in kidney 
JAK2increases prenylationISOJak2 (Mus musculus)149735351RGDcisplatin increases phosphorylation of Jak2 protein in kidney 
JAK2decreases expressionEXP 6480464CTDCisplatin results in decreased expression of JAK2 mRNAPMID:27392435
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