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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70988
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akap12
Name: A-kinase anchoring protein 12
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akap12affects response to substanceISOAKAP12 (Homo sapiens)6480464CTDAKAP12 protein affects the susceptibility to CisplatinPMID:16217747
Akap12decreases expressionISOAKAP12 (Homo sapiens)6480464CTDCisplatin results in decreased expression of AKAP12 mRNAPMID:27392435
Akap12increases expressionISOAkap12 (Mus musculus)6480464CTDCisplatin results in increased expression of AKAP12 mRNAPMID:21151649
Akap12multiple interactionsISOAKAP12 (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in decreased expression of AKAP12 mRNA; Cisplatin affects the reaction [Piroxicam results in decreased expression of AKAP12 mRNA]PMID:21858171 PMID:27392435
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