Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631426
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atp5mk
Name: ATP synthase membrane subunit K
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atp5mkincreases expressionEXP 6480464CTDCisplatin results in increased expression of ATP5MK proteinPMID:22023808
Atp5mkdecreases expressionISOATP5MK (Homo sapiens)6480464CTDCisplatin results in decreased expression of ATP5MK mRNAPMID:27392435
Go Back to source page   Continue to Ontology report