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RGD ID: 62279
Species: Mus musculus
RGD Object: Gene
Symbol: Phgdh
Name: 3-phosphoglycerate dehydrogenase
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:619876480464CTDCisplatin results in decreased expression of PHGDH mRNA

decreases expressionISORGD:7372246480464CTDCisplatin results in decreased expression of PHGDH protein

increases expressionISORGD:7372246480464CTDCisplatin results in increased expression of PHGDH mRNA

multiple interactionsISORGD:7372246480464CTDCisplatin promotes the reaction [Piroxicam results in decreased expression of PHGDH mRNA]

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.