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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnc
Name: tenascin C
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tncdecreases expressionEXP 6480464CTDCisplatin results in decreased expression of TNC mRNAPMID:22023808
Tncincreases expressionEXP 6480464CTDCisplatin results in increased expression of TNC mRNAPMID:24880025
Tncaffects expressionISOTNC (Homo sapiens)6480464CTDCisplatin affects the expression of TNC mRNAPMID:23300844
Tncdecreases expressionISOTNC (Homo sapiens)6480464CTDCisplatin results in decreased expression of TNC mRNAPMID:27392435
Tncdecreases expressionISOTnc (Mus musculus)6480464CTDCisplatin results in decreased expression of TNC mRNAPMID:21151649
Tncmultiple interactionsISOTNC (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in decreased expression of TNC mRNA; [Cisplatin co-treated with Paclitaxel] affects the expression of TNC mRNAPMID:20705681 PMID:27392435
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