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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620668
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Synpo
Name: synaptopodin
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Synpodecreases expressionEXP 6480464CTDCisplatin results in decreased expression of SYNPO proteinPMID:37102204
Synpomultiple interactionsEXP 6480464CTD[Cisplatin co-treated with clemizole] results in decreased expression of SYNPO protein; clemizole inhibits the reaction [Cisplatin results in decreased expression of SYNPO protein]PMID:37102204
Synpomultiple interactionsISOSYNPO (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in decreased expression of SYNPO mRNAPMID:27392435
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