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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620667
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dck
Name: deoxycytidine kinase
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dckincreases expressionISORGD:13447476480464CTDCisplatin results in increased expression of DCK mRNA

PMID:27594783
Dckincreases phosphorylationISORGD:15523526480464CTDCisplatin results in increased phosphorylation of DCK protein

PMID:22006019
Dckmultiple interactionsISORGD:13447476480464CTD[Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of DCK mRNA

PMID:30871063
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.