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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61912
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc6a6
Name: solute carrier family 6 member 6
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:690046480464CTDCisplatin results in decreased expression of SLC6A6 mRNA

PMID:27594783
decreases response to substanceISORGD:622056480464CTDTAUT protein results in decreased susceptibility to Cisplatin

PMID:21220912
increases expressionISORGD:690046480464CTDCisplatin results in increased expression of SLC6A6 mRNA

PMID:27392435
multiple interactionsISORGD:690046480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of SLC6A6 mRNA

PMID:27392435
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.