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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3907
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Clu
Name: clusterin
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cluaffects expressionEXP 6480464CTDCisplatin affects the expression of CLU mRNAPMID:20623750
Cludecreases expressionEXP 6480464CTDCisplatin results in decreased expression of CLU mRNA; Cisplatin results in decreased expression of CLU proteinPMID:18172885 PMID:22023808
Cluincreases expressionEXP 6480464CTDCisplatin results in increased expression of CLU mRNA; Cisplatin results in increased expression of CLU proteinPMID:15033597 PMID:18289764 PMID:20716785 PMID:22581811 PMID:24863737
Cluincreases secretionEXP 6480464CTDCisplatin results in increased secretion of CLU proteinPMID:28885000
Cludecreases response to substanceISOCLU (Homo sapiens)6480464CTDCLU protein results in decreased susceptibility to CisplatinPMID:15955107
Cluincreases expressionISOClu (Mus musculus)6480464CTDCisplatin results in increased expression of CLU mRNAPMID:21151649
Clumultiple interactionsISOCLU (Homo sapiens)6480464CTDCisplatin promotes the reaction [jinfukang results in increased expression of CLU mRNA]; jinfukang promotes the reaction [Cisplatin results in increased expression of CLU mRNA]PMID:27392435
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