Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3771
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat1decreases expressionISOStat1 (Mus musculus)6480464CTDCisplatin results in decreased expression of STAT1 mRNAPMID:21151649
Stat1decreases response to substanceISOSTAT1 (Homo sapiens)6480464CTDSTAT1 results in decreased susceptibility to CisplatinPMID:21571862
Stat1increases expressionISOStat1 (Mus musculus)6480464CTDCisplatin results in increased expression of STAT1 mRNAPMID:26546572
Stat1increases phosphorylationISOStat1 (Mus musculus)6480464CTDCisplatin results in increased phosphorylation of STAT1 proteinPMID:37395757
Stat1increases response to substanceISOSTAT1 (Homo sapiens)6480464CTDSTAT1 protein modified form results in increased susceptibility to CisplatinPMID:21571862
Stat1multiple interactionsISOSTAT1 (Homo sapiens)6480464CTD[HDAC4 results in increased activity of STAT1] which results in decreased susceptibility to Cisplatin; [IFNG protein results in increased phosphorylation of STAT1 protein] which results in decreased susceptibility to CisplatinPMID:20814891 PMID:21571862
Stat1multiple interactionsISOStat1 (Mus musculus)6480464CTD4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of STAT1 mRNA]; apelin-13 peptide inhibits the reaction [Cisplatin results in increased phosphorylation of STAT1 protein]PMID:26546572 PMID:37395757
Go Back to source page   Continue to Ontology report