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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2decreases expressionEXP 6480464CTDCisplatin results in decreased expression of SOD2 proteinPMID:36372261
Sod2multiple interactionsEXP 6480464CTDSodium Acetate inhibits the reaction [Cisplatin results in decreased expression of SOD2 protein]PMID:36372261
Sod2decreases expressionISOSod2 (Mus musculus)6480464CTDCisplatin results in decreased expression of SOD2 mRNA; Cisplatin results in decreased expression of SOD2 proteinPMID:21570986 PMID:24865317 PMID:36372261
Sod2decreases response to substanceISOSOD2 (Homo sapiens)6480464CTDSOD2 protein results in decreased susceptibility to CisplatinPMID:17523305
Sod2increases expressionISOSod2 (Mus musculus)6480464CTDCisplatin results in increased expression of SOD2 mRNAPMID:32428544
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDCisplatin results in increased expression of SOD2 mRNA; Cisplatin results in increased expression of SOD2 proteinPMID:25450742
Sod2multiple interactionsISOSod2 (Mus musculus)6480464CTD[2-tert-butylhydroquinone co-treated with Cisplatin] results in increased expression of SOD2 mRNA; [Cisplatin co-treated with Lutein] results in decreased expression of SOD2 mRNA; Sodium Acetate inhibits the reaction [Cisplatin results in decreased expression of SOD2 protein]PMID:24865317 PMID:32428544 PMID:36372261
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTDCisplatin results in decreased expression of and results in increased acetylation of SOD2 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Cisplatin results in decreased expression of and results in increased acetylation of SOD2 protein]; SIRT3 protein inhibits the reaction [Cisplatin results in increased acetylation of SOD2 protein]; SIRT3 protein promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Cisplatin results in decreased expression of and results in increased acetylation of SOD2 protein]]PMID:27722009
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