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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3227
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Odc1
Name: ornithine decarboxylase 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Odc1decreases expressionEXP 6480464CTDCisplatin results in decreased expression of ODC1 mRNAPMID:18289764
Odc1increases expressionEXP 6480464CTDCisplatin results in increased expression of ODC1 mRNAPMID:18172885
Odc1decreases expressionISOOdc1 (Mus musculus)6480464CTDCisplatin results in decreased expression of ODC1 mRNAPMID:21151649
Odc1multiple interactionsISOODC1 (Homo sapiens)6480464CTDCisplatin promotes the reaction [jinfukang results in decreased expression of ODC1 mRNA]; jinfukang promotes the reaction [Cisplatin results in decreased expression of ODC1 mRNA]PMID:27392435
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