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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2904
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il7
Name: interleukin 7
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il7decreases expressionEXP 6480464CTDCisplatin results in decreased expression of IL7 mRNAPMID:35842499
Il7increases expressionISOIL7 (Homo sapiens)6480464CTDCisplatin results in increased expression of IL7 mRNAPMID:27392435
Il7multiple interactionsISOIl7 (Mus musculus)6480464CTD[Cisplatin co-treated with vinorelbine] results in increased expression of IL7 proteinPMID:21544650
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