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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDCisplatin results in increased expression of HMOX1 mRNA, Cisplatin results in increased expression of HMOX1 protein

PMID:16837816, PMID:18172885, PMID:18289764, PMID:18992762, PMID:22023808, PMID:24291008, PMID:28902463
multiple interactionsEXP 6480464CTD1, 3-dimethylthiourea promotes the reaction [Cisplatin results in increased expression of HMOX1 protein], acetovanillone inhibits the reaction [Cisplatin results in increased expression of HMOX1 mRNA], montelukast inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein], Selenium inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein]

PMID:16837816, PMID:18992762, PMID:24291008, PMID:28902463
decreases response to substanceISORGD:7309016480464CTDHMOX1 protein results in decreased susceptibility to Cisplatin

PMID:22490514
increases expressionISORGD:107176480464CTDCisplatin results in increased expression of HMOX1 mRNA, Cisplatin results in increased expression of HMOX1 protein

PMID:15701814, PMID:19833167, PMID:20605904, PMID:25043994, PMID:27815112, PMID:31153982
increases expressionISORGD:7309016480464CTDCisplatin results in increased expression of HMOX1 mRNA, Cisplatin results in increased expression of HMOX1 protein

PMID:19561079, PMID:25450742, PMID:25596134, PMID:26260164
multiple interactionsISORGD:107176480464CTD1, 3-dimethylthiourea inhibits the reaction [[Cisplatin co-treated with IL6 gene mutant form] results in increased expression of HMOX1 mRNA], 1, 3-dimethylthiourea inhibits the reaction [Cisplatin results in increased expression of HMOX1 mRNA], [Cisplatin co-treated with IL6 gene mutant form] results in increased expression of HMOX1 mRNA, Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein], Hemin promotes the reaction [Cisplatin results in increased expression of HMOX1 protein], hesperetin promotes the reaction [Cisplatin results in increased expression of HMOX1 protein], IL6 gene mutant form promotes the reaction [Cisplatin results in increased expression of HMOX1 mRNA], NFE2L2 protein promotes the reaction [Cisplatin results in increased expression of HMOX1 mRNA], NFE2L2 protein promotes the reaction [Cisplatin results in increased expression of HMOX1 protein], zinc protoporphyrin inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein]

PMID:15701814, PMID:19833167, PMID:20605904, PMID:23384965, PMID:25043994, PMID:27815112, PMID:31153982
multiple interactionsISORGD:7309016480464CTD[Cisplatin co-treated with hesperetin] results in increased expression of HMOX1 protein, [Cisplatin co-treated with jinfukang] results in increased expression of HMOX1 mRNA

PMID:27392435, PMID:31153982
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.