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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2180
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atp7b
Name: ATPase copper transporting beta
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atp7baffects localizationISOAtp7b (Mus musculus)6480464CTDCisplatin affects the localization of ATP7B proteinPMID:20433422
Atp7baffects response to substanceISOATP7B (Homo sapiens)6480464CTDATP7B mRNA affects the susceptibility to CisplatinPMID:18610736
Atp7bdecreases response to substanceISOAtp7b (Mus musculus)6480464CTDATP7B protein results in decreased susceptibility to CisplatinPMID:16170571 PMID:20433422
Atp7bdecreases response to substanceISOATP7B (Homo sapiens)6480464CTDATP7B protein results in decreased susceptibility to CisplatinPMID:10728692 PMID:12509969
Atp7bincreases secretionISOATP7B (Homo sapiens)6480464CTDATP7B protein results in increased secretion of CisplatinPMID:10728692
Atp7bmultiple interactionsISOATP7B (Homo sapiens)6480464CTDATP7B protein binds to and results in increased metabolism of Cisplatin; Cisplatin results in increased stability of and results in increased activity of and affects the localization of ATP7B protein polymorphismPMID:21406592 PMID:23751120
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