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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1607576
Species: Mus musculus
RGD Object: Gene
Symbol: Mir98
Name: microRNA 98
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mir98affects uptakeISORGD:13441946480464CTDMIR98 mRNA affects the uptake of Cisplatin

PMID:27270317
Mir98decreases expressionISORGD:13441946480464CTDCisplatin results in decreased expression of MIR98

PMID:21274007
Mir98multiple interactionsISORGD:13441946480464CTD[MIR98 mRNA affects the uptake of Cisplatin] which affects the abundance of cisplatin-DNA adduct

PMID:27270317
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.