Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1607082
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	TUBA1A
Name:	tubulin alpha 1a

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
TUBA1A	decreases expression	EXP		6480464	CTD	Cisplatin results in decreased expression of TUBA1A mRNA	PMID:27392435
TUBA1A	increases expression	EXP		6480464	CTD	Cisplatin results in increased expression of TUBA1A mRNA; Cisplatin results in increased expression of TUBA1A protein	PMID:21924258 PMID:27594783
TUBA1A	multiple interactions	EXP		6480464	CTD	[Cisplatin co-treated with jinfukang] results in decreased expression of TUBA1A mRNA; Folic Acid affects the reaction [Cisplatin affects the expression of TUBA1A mRNA]	PMID:16898872 PMID:27392435
TUBA1A	increases expression	ISO	Tuba1a (Mus musculus)	6480464	CTD	Cisplatin results in increased expression of TUBA1A mRNA	PMID:25270620
TUBA1A	increases expression	ISO	Tuba1a (Rattus norvegicus)	6480464	CTD	Cisplatin results in increased expression of TUBA1A protein	PMID:22023808

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