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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1603769
Species: Homo sapiens
RGD Object: Gene
Symbol: MIR495
Name: microRNA 495
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MIR495multiple interactionsEXP 6480464CTD[MIR495 mRNA results in decreased expression of ATP7A protein] which results in increased susceptibility to Cisplatin; ATP7A protein inhibits the reaction [MIR495 mRNA results in increased uptake of and results in increased susceptibility to Cisplatin]; MIR495 mRNA results in increased uptake of and results in increased susceptibility to CisplatinPMID:24038379
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