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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593163
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sprr1a
Name: small proline-rich protein 1A
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sprr1aincreases expressionISOSprr1a (Mus musculus)6480464CTDCisplatin results in increased expression of SPRR1A proteinPMID:31493026
Sprr1amultiple interactionsISOSprr1a (Mus musculus)6480464CTD[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of SPRR1A mRNA; [SLC22A2 protein affects the susceptibility to Cisplatin] which affects the expression of SPRR1A proteinPMID:23625948 PMID:31493026
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