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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1592221
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mlkl
Name: mixed lineage kinase domain like pseudokinase
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mlklaffects expressionISOMLKL (Homo sapiens)6480464CTDCisplatin affects the expression of MLKL mRNAPMID:23300844
Mlklincreases expressionISOMlkl (Mus musculus)6480464CTDCisplatin results in increased expression of MLKL proteinPMID:32888910
Mlklmultiple interactionsISOMlkl (Mus musculus)6480464CTDNUMB protein affects the reaction [Cisplatin results in increased expression of MLKL protein]PMID:32888910
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