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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553412
Species: Mus musculus
RGD Object: Gene
Symbol: Angptl4
Name: angiopoietin-like 4
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Angptl4multiple interactionsEXP 6480464CTD[Cisplatin co-treated with RELB mutant form] results in decreased expression of ANGPTL4 mRNAPMID:23625948
Angptl4affects expressionISOANGPTL4 (Homo sapiens)6480464CTDCisplatin affects the expression of ANGPTL4 mRNAPMID:23300844
Angptl4increases expressionISOANGPTL4 (Homo sapiens)6480464CTDCisplatin results in increased expression of ANGPTL4 mRNAPMID:25596134 PMID:33545341
Angptl4multiple interactionsISOANGPTL4 (Homo sapiens)6480464CTD[Cisplatin co-treated with Paclitaxel] results in increased expression of ANGPTL4 mRNAPMID:20705681
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