GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Fasl | increases response to substance | EXP | | 6480464 | CTD | FASL protein results in increased susceptibility to Cisplatin | PMID:9182976 | Fasl | multiple interactions | EXP | | 6480464 | CTD | [Cisplatin co-treated with vinorelbine] results in decreased expression of FASL mRNA | PMID:21544650 | Fasl | increases expression | ISO | FASLG (Homo sapiens) | 6480464 | CTD | Cisplatin results in increased expression of FASLG mRNA; Cisplatin results in increased expression of FASLG protein | PMID:16957513 PMID:20878077 PMID:21216935 | Fasl | increases expression | ISO | Faslg (Rattus norvegicus) | 6480464 | CTD | Cisplatin results in increased expression of FASLG mRNA; Cisplatin results in increased expression of FASLG protein | PMID:12684229 PMID:29216766 | Fasl | multiple interactions | ISO | FASLG (Homo sapiens) | 6480464 | CTD | [andrographolide co-treated with Cisplatin] promotes the reaction [FAS protein binds to FASLG protein]; [andrographolide co-treated with Cisplatin] results in increased expression of FASLG mRNA; [andrographolide co-treated with Cisplatin] results in increased expression of FASLG protein; [Cisplatin co-treated with FASLG protein] results in decreased expression of BID protein; [Cisplatin co-treated with FASLG protein] results in increased activity of CASP3 protein; [Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein; [Cisplatin co-treated with FASLG protein] results in increased activity of CASP9 protein; [Cisplatin co-treated with fisetin] results in increased expression of FASLG protein; [nutlin 3 promotes the reaction [FAS protein binds to FASLG protein]] which results in increased susceptibility to Cisplatin; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in decreased expression of BID protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP9 protein]; BCL2 protein inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein]; BCL2 protein inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP9 protein]; Y 27632 inhibits the reaction [Cisplatin results in increased expression of FASLG mRNA] | PMID:17574045 PMID:20878077 PMID:21216935 PMID:21509038 PMID:24563380 | Fasl | multiple interactions | ISO | Faslg (Rattus norvegicus) | 6480464 | CTD | 1,3-dimethylthiourea inhibits the reaction [Cisplatin results in increased expression of FASLG mRNA]; vanillin inhibits the reaction [Cisplatin results in increased expression of FASLG protein] | PMID:12684229 PMID:29216766 | | ||||||||||||||||||||||
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